AbstractAlthough benign prostatic hyperplasia (BPH) is one of the most common disease processes affecting the aging man, surprisingly little is known about its pathophysiology [1]. Despite intense research efforts in the past four to five decades to find the underlying cause of prostatic growth in older men, cause and effect relationships have not been established. Previously held notions that the clinical symptoms of BPH (prostatism) are simply due to a mass-related increase in urethral resistance are too simplistic. It is now clear that a significant portion of the symptoms are caused by obstruction-induced detrusor dysfunction. Moreover, obstruction may induce a variety of neural alterations in the bladder and prostate that contribute to symptomatology. Undoubtedly, the constellation of cellular pathologies that give rise to the symptoms of BPH will be far more complex than we currently realize. Only by revealing these complexities, however, will we be able to successfully design alternative strategies to treat, and possibly prevent, BPH. Show
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Rights and permissionsCopyright information© 2003 Current Medicine, Inc. About this chapterCite this chapterMcConnell, J.D. (2003). The Epidemiology and Pathophysiology of Benign Prostatic Hyperplasia. In: Bruskewitz, R.C. (eds) Atlas of the Prostate. Current Medicine Group, London. https://doi.org/10.1007/978-1-4615-6505-5_1 Download citation
What is pathophysiology of benign prostatic hyperplasia?Pathophysiology of BPH
As the lumen of the prostatic urethra narrows and lengthens, urine outflow is progressively obstructed. Increased pressure associated with micturition and bladder distention can progress to hypertrophy of the bladder detrusor, trabeculation, cellule formation, and diverticula.
Is BPH pathological or physiological?Benign prostatic hyperplasia (BPH) is a pathologic process that contributes to, but is not the sole cause of, lower urinary tract symptoms (LUTS) in aging men.
What are the 4 factors that contribute to BPH?Risk factors. Aging. Prostate gland enlargement rarely causes signs and symptoms in men younger than age 40. ... . Family history. Having a blood relative, such as a father or a brother, with prostate problems means you're more likely to have problems.. Diabetes and heart disease. ... . Lifestyle.. What is the most common cause of benign prostatic hyperplasia?Hormones from the testis may be the main factor. For example, as men age, the amount of active testosterone in the blood declines. Estrogen levels stay the same. BPH may occur when these hormone changes trigger prostate cell growth.
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