Elavil overdose; Adepril overdose; Endep overdose; Enovil overdose; Trepiline overdose Amitriptyline hydrochloride is a type of prescription medicine called a tricyclic antidepressant. It is used to treat depression. Amitriptyline hydrochloride overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual
overdose. If you or someone you are with has an overdose, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. Amitriptyline
can be harmful in large amounts. Amitriptyline hydrochloride is a prescription medicine. It is sold under these brand names: Other medicines may also contain amitriptyline hydrochloride. SymptomsBelow are symptoms of an amitriptyline hydrochloride overdose in different parts of the body. These symptoms may occur more often or be more severe in people who also take certain other medicines that affect serotonin, a chemical in the brain. AIRWAYS AND LUNGS
BLADDER AND KIDNEYS
EYES, EARS, NOSE, AND THROAT
HEART AND BLOOD
NERVOUS SYSTEM
STOMACH AND INTESTINES
Home CareThis can be a very serious overdose. Seek medical help right away. Before Calling EmergencyHave this information ready:
Poison ControlYour local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions. This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. What to Expect at the Emergency RoomTake the container to the hospital with you, if possible. The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Tests that may be done include:
Treatment may include:
Outlook (Prognosis)An amitriptyline hydrochloride overdose can be very serious. People who swallow too much of this drug are almost always admitted to the hospital. How well someone does depends on how much of the drug was swallowed and how quickly treatment is given. The faster a person gets medical help, the better the chance of recovery. Complications such as pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability. Death can occur. ReferencesAronson JK. Tricyclic antidepressants. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:146-169. Levine MD, Ruha AM. Antidepressants. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 146. Version InfoLast reviewed on: 11/13/2021 Reviewed by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Which emergency treatments are the priority for a client who intentionally took an overdose of tricyclic antidepressant?Initial treatment of an acute overdose includes gastric decontamination. This is achieved by giving activated charcoal, which adsorbs the drug in the gastrointestinal tract either by mouth or via a nasogastric tube. Activated charcoal is most useful if given within 1 to 2 hours of ingestion.
Which antagonist may be used to treat an overdose of oxazepam?Flumazenil, a specific benzodiazepine receptor antagonist indicated for the complete or partial reversal of the sedative effects of benzodiazepines in the management of benzodiazepine overdosage, can lead to withdrawal and adverse reactions, including seizures, particularly in the context of mixed overdosage with drugs ...
Which of the following adverse reaction would the nurse expect to find in a client taking amitriptyline?The clinical symptoms of amitriptyline toxicity include neurological, cardiac, and anticholinergic adverse reactions. Neurological symptoms include sedation, seizure, and coma. Cardiac symptoms include tachycardia, hypotension, and conduction abnormalities, including QTc prolongation.
Which side effect would the nurse monitor for when administering a selective serotonin reuptake inhibitor SSRI?Possible side effects of SSRIs may include, among others: Nausea, vomiting or diarrhea. Headache. Drowsiness.
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