Which of the following antibodies could be produced by a patient with the McLeod phenotype

McLeod phenotype is one of the rare blood cell types, defined as those that occur at a frequency of 1:1,000 or less. We have screened donors for rare cells since 1987 using mouse monoclonal antibodies (MAbs). In the western regions of Japan a total of 16,160,714 donor red cells were screened using mouse anti-Kell MAbs (anti-k, anti-Ku and anti-K14) during 1987–2005. We found 182 blood cells with McLeod phenotype or Kmod and 286 with Ko. To identify McLeod phenotype, we examine the expression level of Kell antigens by flow cytometry, cell morphology (acanthocytes) by scanning electron microscopy, red cells of family members and the XK gene. As a result, we identified three donors with McLeod phenotype (two subsequently developed McLeod syndrome) and two with McLeod-like phenotype. Nine donors are now registered as McLeod phenotype in all Japan.

Keywords

• Hematopoietic Stem Cell Transplantation
• Chronic Granulomatous Disease
• Cord Blood Transplantation
• Chronic Granulomatous Disease Patient
• Blood Group System

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References

1. Allen FH, Krabbe SM, Corcon PA (1961) A new phenotype (McLeod) in the Kell blood-group system. Vox Sang 6:555–560.

   CrossRef  PubMed  Google Scholar 

2. Daniels GL, Fletcher A, Garratty G, Henry S, Jorgensen J, Judd WJ, Levene C, Lomas-Francis C, Moulds JJ, Moulds JM, Moulds M, Overbeeke M, Reid ME, Rouger P, Scott M, Sistonen P, Smart E, Tani Y, Wendel S, Zelinski T, International Society of Blood Transfusion (2004) Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigens. Vox Sang 87:304–316.

   CrossRef  CAS  PubMed  Google Scholar 

3. Enomoto T, Omura K, Hando K, Hattori T, Obara T, Ishijima A, Kozaki N, Hatakeyama H, Tsunetama H, Uchikawa M (1994) A case of McLeod phenotype detected in Japanese blood donors [in Japanese]. Jpn J Transfus Med 40:361.

   Google Scholar 

4. Hanaoka N, Hanaoka N, Yoshida K, Nakamura A, Furihata K, Seo T, Tani Y, Takahashi J, Ikeda S, Hanyu N (1999) A novel frameshift mutation in the McLeod syndrome gene in a Japanese family. J Neurol Sci 165:6–9.

   CrossRef  CAS  PubMed  Google Scholar 

5. Ishikawa S, Tachibana N, Tabata KI, Fujimori N, Hayashi RI, Takahashi J, Ikeda SI, Hanyu N (2000) Muscle CT scan findings in McLeod syndrome and chorea-acanthocytosis. Muscle Nerve 23:1113–1116.

   CrossRef  CAS  PubMed  Google Scholar 

6. Kageyama Y, Kodama Y, Tadano M, Yamamoto S, Ichikawa K (2000) A case of chorea-acanthocytosis with dilated cardiomyopathy and myopathy. Clin Neurol 40:816–820.

   CAS  Google Scholar 

7. Kawakami T, Takiyama Y, Sakoe K, Ogawa T, Yoshioka T, Nishizawa M, Reid ME, Kobayashi O, Nonaka I, Nakano I (1999) A case of McLeod syndrome with unusually severe myopathy. J Neurol Sci 166:36–39.

   CrossRef  CAS  PubMed  Google Scholar 

8. Lee S, Russo D, Redman C (2000) Functional and structural aspects of the Kell Blood group system. Transfus Med Rev 14:93–103.

   CrossRef  CAS  PubMed  Google Scholar 

9. Suzuki N, Hatakeyama N, Yamamoto M, Mizue N, Kuroiwa Y, Yod M, Takahashi J, Tani Y, Tsutsumia H (2007) Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. Int J Hematol 85:70–72.

   CrossRef  PubMed  Google Scholar 

10. Takahashi J, Fuchihara T, Horie H, Ishii H, Yoshimura K, Toyota Y, Seno T, Yamano T, Nagao N, Okubo Y, Yamaguchi H (1989) A family of McLeod phenotype detected by monoclonal anti-K2 [in Japanese]. Jpn J Transfus Med 35:206.

    Google Scholar 

11. Takahashi Y, Tsutida N, Konishi Y, Karino I, Ozaki E, Kagami T, Tsutida H, Kojima I (1995) Two Japanese blood donors with McLeod phenotype identified [in Japanese]. Jpn J Transfus Med 41:81.

    Google Scholar 

12. Tani Y, Takahashi J, Tanaka M, Hirayama F, Hatakeyama N, Yamamoto M, Kuroiwa Y, Mizue N, Yoda M, Sakiyama Y, Suzuki N, Shibata H (2006) A case of a patient with McLeod phenotype and CGD who did not produce anti-Kx regardless of packed red cells transfusions from random donors during nonmyeloablative cord blood transplantation. Vox Sang 91:165(P-341).

    Google Scholar 

13. Tomonari Y, Toyota T, Watanabe S, Watanabe Y, Eto K, Yoshitake N, Yoshimura T, Miyanari Y, Taguchi T, Kodama T, Seno T, Nagao N, Okubo Y, Yamaguchi H (1989) Two blood donors of McLeod phenotype found in blood donors [in Japanese]. J Jpn Blood Programme 12:205.

    Google Scholar 

14. Tsutida H, Fujisawa N, Ozaki E, Takahashi Y, Kagami T, Mito S, Murata G, Tsuneyama H, Uchikawa M, Nakajima I (2000) A donor red cell considered as McLeod phenotype [in Japanese]. Jpn J Transfus Med 46:25.

    Google Scholar 

15. Uchida K, Nakajima K, Shima H, Ichiba K, Seno T, Okubo Y, Yamaguchi H (1992) The first example of the McLeod phenotype in a Japanese baby with chronic granulomatous disease. Transfusion 32:691.

    CrossRef  CAS  PubMed  Google Scholar 

16. Ueyama H, Kumamoto T, Nagao S, Masuda T, Sugihara R, Fujimoto S, Tsuda T (2000) A novel mutation of the McLeod syndrome gene in a Japanese family. J Neurol Sci 176:151–154.

    CrossRef  CAS  PubMed  Google Scholar 

17. Yoda M, Yoshida K, Ohyanagi N, Ohsaki M, Yoshimura H, Hatano N, Ariga T, Sakiyama Y (2006) A case of X-linked chronic granulomatous disease associated with McLeod syndrome. J Jpn Pediatr Soc 110:38–41.

    Google Scholar 

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Authors and Affiliations

1. Japanese Red Cross Osaka Blood Center, 2-4-43, Morinomiya Joto-ku, Osaka, 536-8505, Japan

   Y. Tani, J. Takahashi, M. Tanaka & H. Shibata

Authors

1. Y. Tani

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2. J. Takahashi

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3. M. Tanaka

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4. H. Shibata

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Editor information

Editors and Affiliations

1. Movement Disorders Clinic Department of Neurology, James J. Peters Veterans Affairs Medical Center, 130 W. Kingsbridge Road (127), Bronx, NY 10468

   Ruth H. Walker

2. Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA

   Ruth H. Walker

3. Department of Medical Genetics Cambridge Institute for Medical Research Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2XY, UK

   Shinji Saiki

4. Neurologische Klinik, Ludwig-Maximilians-Universität, D-81366, München, Germany

   Adrian Danek

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Tani, Y., Takahashi, J., Tanaka, M., Shibata, H. (2008). McLeod Syndrome: A Perspective from Japanese Blood Centers. In: Walker, R.H., Saiki, S., Danek, A. (eds) Neuroacanthocytosis Syndromes II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71693-8_11

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