The nurse anticipates which signs during the exudative phase of acute respiratory distress syndrome?

1. Ali NN, Edgar AJ, Samadikuchaksaraei A, Timson CM, Romanska HM, Polak JM, Bishop AE. Derivation of type II alveolar epithelial cells from murine embryonic stem cells. Tissue Eng. 2002;8(4):541–550. doi: 10.1089/107632702760240463. [PubMed] [CrossRef] [Google Scholar]

2. Archer S, Rich S. Primary pulmonary hypertension: a vascular biology and translational research “work in progress” Circulation. 2000;102(22):2781–2791. [PubMed] [Google Scholar]

3. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275(5302):964–967. doi: 10.1126/science.275.5302.964. [PubMed] [CrossRef] [Google Scholar]

4. Avery RK. Special considerations regarding CMV in lung transplantation. Transpl Infect Dis. 1999;1(Suppl. 1):13–18. [PubMed] [Google Scholar]

5. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(3 Pt 1):818–824. [PubMed] [Google Scholar]

6. Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science. 2000;290(5497):1775–1779. doi: 10.1126/science.290.5497.1775. [PubMed] [CrossRef] [Google Scholar]

7. Breen PH, Schumacker PT, Hedenstierna G, Ali J, Wagner PD, Wood LD. How does increased cardiac output increase shunt in pulmonary edema? J Appl Physiol. 1982;53(5):1273–1280. [PubMed] [Google Scholar]

8. Brown LM, Rannels SR, Rannels DE. Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease. Respir Res. 2001;2(6):340–347. doi: 10.1186/rr84. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

9. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Regnier B. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA. 1995;274(12):968–974. doi: 10.1001/jama.274.12.968. [PubMed] [CrossRef] [Google Scholar]

10. Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med. 2005;172(7):854–860. doi: 10.1164/rccm.200410-1325OC. [PubMed] [CrossRef] [Google Scholar]

11. Campbell AI, Kuliszewski MA, Stewart DJ. Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits moncrotaline-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 1999;21(5):567–575. [PubMed] [Google Scholar]

12. Campbell AI, Zhao Y, Sandhu R, Stewart DJ. Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotamine-induced pulmonary hypertension. Circulation. 2001;104(18):2242–2248. [PubMed] [Google Scholar]

13. Chan A, Allen R. Bronchiolitis obliterans: an update. Curr Opin Pulm Med. 2004;10(2):133–141. doi: 10.1097/00063198-200403000-00008. [PubMed] [CrossRef] [Google Scholar]

14. Chaparro C, Kesten S. Infections in lung transplant recipients. Clin Chest Med. 1997;18(2):339–351. doi: 10.1016/S0272-5231(05)70383-X. [PubMed] [CrossRef] [Google Scholar]

15. Coraux C, Hilmi C, Rouleau M, Spadafora A, Hinnrasky J, Ortonne JP, Dani C, Aberdam D. Reconstituted skin from murine embryonic stem cells. Curr Biol. 2003;13(10):849–853. doi: 10.1016/S0960-9822(03)00296-3. [PubMed] [CrossRef] [Google Scholar]

16. Coraux C, Nawrocki-Raby B, Hinnrasky J, Kileztky C, Gaillard D, Dani C, Puchelle E. Embryonic stem cells generate airway epithelial tissue. Am J Respir Cell Mol Biol. 2004;32(2):87–95. doi: 10.1165/rcmb.2004-0079RC. [PubMed] [CrossRef] [Google Scholar]

17. Crouser ED, Dorinsky PM. Gastrointestinal tract dysfunction in critical illness: pathophysiology and interaction with acute lung injury in adult respiratory distress syndrome/multiple organ dysfunction syndrome. N Horiz. 1994;2(4):476–487. [PubMed] [Google Scholar]

18. Davidson TA, Caldwell ES, Curtis JR, Hudson LD, Steinberg KP. Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. JAMA. 1999;281(4):354–360. doi: 10.1001/jama.281.4.354. [PubMed] [CrossRef] [Google Scholar]

19. Deitch EA. Multiple organ failure: pathogenesis and potential future therapy. Ann Surg. 1992;216(2):117–134. doi: 10.1097/00000658-199208000-00002. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

20. Dupont H, LeCorre R, Fierobe L, Cheval C, Moine P, Timsit JF. Efficacy of inhaled nitric oxide as rescue therapy during severe ARDS: survival and factors associated with the first responses. J Crit Care. 1999;14(3):107–113. doi: 10.1016/S0883-9441(99)90022-9. [PubMed] [CrossRef] [Google Scholar]

21. Eglitis MA, Mezey E. Hematopoietic cells differentiate into both microglia in the brains of adult mice. Proc Natl Acad Sci USA. 1997;94(8):4080–4085. doi: 10.1073/pnas.94.8.4080. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

22. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292(5819):154–156. doi: 10.1038/292154a0. [PubMed] [CrossRef] [Google Scholar]

23. Ezri T, Kunichezky S, Eliraz A, Soroker D, Halperin D, Schattner A. Bronchiolitis obliterans-current concepts. Q J Med. 1994;87(1):1–10. [PMC free article] [PubMed] [Google Scholar]

24. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. Muscle regeneration by bone marrow derived myogenic progenitors. Science. 1998;279(5356):1528–1530. doi: 10.1126/science.279.5356.1528. [PubMed] [CrossRef] [Google Scholar]

25. Fowler AA, Hamman RF, Good JT, Benson KN, Baird M, Eberle DJ, Petty TL, Hyers TM. Adult respiratory distress syndrome: risk with common predisposition. Ann Intern Med. 1983;98(5 Pt 1):593–597. [PubMed] [Google Scholar]

26. Frost AE. Bronchiolitis obliterans: the Achilles heel of lung transplantation. Veth K Acad Geneeskd Belg. 2002;64(5):303–319. [PubMed] [Google Scholar]

27. Gao Z, McAlister VC, Williams GM. Repopulation of liver endothelium by bone-marrow-derived cells. Lancet. 2001;357(9260):932–933. doi: 10.1016/S0140-6736(00)04217-3. [PubMed] [CrossRef] [Google Scholar]

28. Gattinoni L, Pelosi P, Vitale G, Pesenti A, D′Andrea L, Mascheroni D. Body position changes redistribute lung computed tomographic density in patient with acute respiratory failure. Anesthesiology. 1991;74(1):15–23. doi: 10.1097/00000542-199101000-00004. [PubMed] [CrossRef] [Google Scholar]

29. Gill M, Dias S, Hattori K, Rivera ML, Hicklin D, Witte L, Girardi L, Yurt R, Himel H, Rafii S. Vascular trauma induces rapid but transient mobilization of VEGFR2(+) AC133(+) endothelial precursor cells. Circ Res. 2001;88(2):167–174. [PubMed] [Google Scholar]

30. Goris RJ, te Bockhorst TP, Nuytinck JK, Gimbrere JS. Multiple organ failure: generalized autodestructive inflammation? Arch Surg. 1985;120(10):1109–1115. [PubMed] [Google Scholar]

31. Grimm PC, Nickerson P, Jeffery J, Savani RC, Gough J, McKenna RM, Stem E, Rush DN. Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal allograft rejection. N Engl J Med. 2001;345(2):93–97. doi: 10.1056/NEJM200107123450203. [PubMed] [CrossRef] [Google Scholar]

32. Grove JE, Lutzko C, Poller J, Hengariu O, Theise ND, Kohn DB, Krause DS. Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am J Respir Cell Mol Biol. 2002;27(6):645–651. [PubMed] [Google Scholar]

33. Harari A, Zimmerli SC, Pantaleo G. Cytomegalovirus (CMV) specific cellular immune responses. Hum Immunol. 2004;65(5):500–506. doi: 10.1016/j.humimm.2004.02.012. [PubMed] [CrossRef] [Google Scholar]

34. Hooper RG. ARDS: inflammation, infections, and corticosteroids. Chest. 1991;100(4):889–890. [PubMed] [Google Scholar]

35. Jones EA, Tosh D, Wilson DI, Lindsay S, Forrester LM. Hepatic differentiation of murine embryonic stem cells. Exp Cell Res. 2002;272(1):15–22. doi: 10.1006/excr.2001.5396. [PubMed] [CrossRef] [Google Scholar]

36. Keller GM. In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol. 1995;7(6):862–869. doi: 10.1016/0955-0674(95)80071-9. [PubMed] [CrossRef] [Google Scholar]

37. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophy Res Commun. 1993;192(2):553–560. doi: 10.1006/bbrc.1993.1451. [PubMed] [CrossRef] [Google Scholar]

38. Klepetko W, Laufer G, Kocher A. Thoracic transplantation and stem cell therapy. Eur J Cardiothorac Surg. 2004;26(Suppl. 1):S57–S58. [PubMed] [Google Scholar]

39. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7(4):430–436. doi: 10.1038/86498. [PubMed] [CrossRef] [Google Scholar]

40. Kollef MH, Schuster D. Acute respiratory distress syndrome. DM. 1996;42(5):266–326. [PubMed] [Google Scholar]

41. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, Champlin RE, Estrov Z. Hepatocytes and epithelial cells of donor origin in recipients of peripheral blood stem cells. N Engl J Med. 2002;346(10):738–746. doi: 10.1056/NEJMoa3461002. [PubMed] [CrossRef] [Google Scholar]

42. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells progenitors of lung alveolar epithelium. Development. 2001;128(24):5181–5188. [PubMed] [Google Scholar]

43. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multilineage engraftment by a single bone marrow derived stem cells. Cell. 2001;105(3):369–377. doi: 10.1016/S0092-8674(01)00328-2. [PubMed] [CrossRef] [Google Scholar]

44. Kubo H. Is cell therapy in acute lung injury a realistic dream? Am J Respir Crit Care Med. 2005;172(7):794–795. doi: 10.1164/rccm.2507006. [PubMed] [CrossRef] [Google Scholar]

45. Kuebler WM, Ying X, Singh B, Issekutz AC, Bhattacharya J. Pressure is proinflammatory in lung venular capillaries. J Clin Invest. 1999;104(4):495–502. [PMC free article] [PubMed] [Google Scholar]

46. Kuebler WM, Parthasarathi K, Wang PM, Bhattacharya J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest. 2000;105(7):905–913. [PMC free article] [PubMed] [Google Scholar]

47. Kugathasan L, Duty AE, Zhao YD, Deng Y, Robb MJ, Keshavjee S, Stewart DJ. Role of angiopoitin-1 in experimental and human pulmonary arterial hypertension. Chest. 2005;128(6_suppl.):633S–642S. doi: 10.1378/chest.128.6_suppl.633S. [PubMed] [CrossRef] [Google Scholar]

48. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6(11):1229–1234. doi: 10.1038/81326. [PubMed] [CrossRef] [Google Scholar]

49. Leach CL, Fuhrman BP, Morin FC3rd, Rath MG. Perfluorocarbon-associated gas exchange (partial liquid ventilation) in respiratory distress syndrome. A prospective randomized, controlled study. Crit Care Med. 1993;21(9):1270–1278. doi: 10.1097/00003246-199309000-00008. [PubMed] [CrossRef] [Google Scholar]

50. Lessard MR. New concepts in mechanical ventilation for ARDS. Can J Anesth. 1996;43(5 Pt 2):R50–R54. [PubMed] [Google Scholar]

51. Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, Frostell CG, Bonde J. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF study group. Am J Respir Crit Care Med. 1999;159(6):1849–1861. [PubMed] [Google Scholar]

52. Lumelsky N, Blondel O, Laeng P, Belassco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001;292(5520):1389–1394. doi: 10.1126/science.1058866. [PubMed] [CrossRef] [Google Scholar]

53. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA. 1981;78(12):7634–7638. doi: 10.1073/pnas.78.12.7634. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

54. Matthay MA, Wierner-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990;142(6 Pt 1):1250–1257. [PubMed] [Google Scholar]

55. Matuschak GM. Liver-lung interactions in critical illness. N Horiz. 1994;2(2):488–504. [PubMed] [Google Scholar]

56. Meduri GU, Chinn AJ, Leeper KV, Wunderink RG, Tolley E, Winer-Muram HT, Khare V, Eltorky M. Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Chest. 1994;105(5):1516–1527. [PubMed] [Google Scholar]

57. Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS) JAMA. 1995;273(4):306–309. doi: 10.1001/jama.273.4.306. [PubMed] [CrossRef] [Google Scholar]

58. Milne ENC, Pistolesi M, Miniati M, Giuntini C. The radiologic distinction of cardiogenic and non-cardiogenic edema. Am J Roentgenol. 1985;144(5):879. [PubMed] [Google Scholar]

59. Moss P, Khan N. CD8(+) T cell immunity to cytomegalovirus. Hum Immunol. 2004;65(5):456–464. doi: 10.1016/j.humimm.2004.02.014. [PubMed] [CrossRef] [Google Scholar]

60. Munford RS, Pugin J. Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med. 2001;163(2):316–321. [PubMed] [Google Scholar]

61. Nagaya N, Kangawa K, Kanda M, Uematsu M, Horio T, Fukuyama N, Hino J, Harada-Shiba M, Okumura H, Tabata Y, et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of entothelial progenitor cells. Circulation. 2003;108(7):889–895. doi: 10.1161/01.CIR.0000079161.56080.22. [PubMed] [CrossRef] [Google Scholar]

62. Nagaya N, Kanda M, Horio T, Kangawa K, Uematsu M, Fukuyama N, Hino J, Harada-Shiba M, Okumura H, Tabata Y, et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytoing action of endothelial progenitor cells. Circulation. 2003;108(7):889–896. doi: 10.1161/01.CIR.0000079161.56080.22. [PubMed] [CrossRef] [Google Scholar]

63. Odorico JS, Kaufman DS, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells. 2001;19(3):193–204. doi: 10.1634/stemcells.19-3-193. [PubMed] [CrossRef] [Google Scholar]

64. Otto WR. Lung epithelial stem cells. J Pathol. 2002;197(4):527–535. doi: 10.1002/path.1160. [PubMed] [CrossRef] [Google Scholar]

65. Paradis I, Yousem S, Griffith B. Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin Chest Med. 1993;14(4):751–763. [PubMed] [Google Scholar]

66. Paulson TE, Spear RM, Silva PD, Peterson BM. High-frequency pressure-control ventilation with high positive end-expiratory pressure in children with acute respiratory distress syndrome. J Pediatr. 1996;129(4):566–578. doi: 10.1016/S0022-3476(96)70122-1. [PubMed] [CrossRef] [Google Scholar]

67. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greengerger JS, Goff JP. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284(5417):1168–1170. doi: 10.1126/science.284.5417.1168. [PubMed] [CrossRef] [Google Scholar]

68. Pistolesi M, Milne EWC, Miniati M, Giuntini C. The vascular pedicle of the heart and the vena azygos. Part II: Acquired heart disease. Radiology. 1984;152(1):9. [PubMed] [Google Scholar]

69. Poulsom R, Alison MR, Forbes SJ, Wright NA. Adult stem cell plasticity. J Pathol. 2002;197(4):441–456. doi: 10.1002/path.1176. [PubMed] [CrossRef] [Google Scholar]

70. Ralph DD, Robertson HT, Weaver LJ, Hlastala MP, Carrico CJ, Hudson LD. Distribution of ventilation and perfusion during positive end-expiratory pressure in the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;131(1):54. [PubMed] [Google Scholar]

71. Rossaint R, Gerlach H, Schmidt-Ruhnke H, Pappert D, Lewandowski K, Steudel W, Falke K. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest. 1995;107(4):1107–1115. [PubMed] [Google Scholar]

72. Roupie E, Dambrosio M, Servillo G, Mentec H, el Atrous S, Beydon L, Brun-Buisson C, Lemaire F, Brochard L. Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome. Am J Respir Crit Care Med. 1995;152(1):121–128. [PubMed] [Google Scholar]

73. Sanajder JI. Strategies to increase alveolar epithelial fluid removal in the injured lung. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1441–1442. [PubMed] [Google Scholar]

74. Schumacker PT, Samsel RW. Oxygen supply and consumption in the adult respiratory distress syndrome. Clin Chest Med. 1990;11(4):715–722. [PubMed] [Google Scholar]

75. Sivan Y, Mor C, al-Jundi S, Newth CJ. Adult respiratory distress syndrome in severely neutropenic children. Pediatr Pulmonol. 1990;8(2):104–108. [PubMed] [Google Scholar]

76. Spencer H, Jaffe A. The potential for stem cell therapy in cystic fibrosis. J R Soc Med. 2004;97(Suppl. 44):52–56. [PMC free article] [PubMed] [Google Scholar]

77. Sprung CL, Long WM, Marcial EH, Schein RM, Parker RE, Shomer T, Brigham KL. Distribution of proteins in pulmonary edema. The value of fractional concentration. Am Rev Respir Dis. 1987;136(4):957. [PubMed] [Google Scholar]

78. St. John RC, Mizer LA, Weisbrode SE, Dorinsky PM. Increased protein permeability in the cat ileum after acid aspiration-induced acute lung injury. Evidence for systemic endothelial injury. Am Rev Respir Dis. 1991;143(5):A805. [Google Scholar]

79. Slutsky AS, Tremblay LN. Multiple system organ failure: is mechanical ventilation a contributing factor? Am J Respir Crit Care Med. 1998;157(6 Pt 1):1721–1725. [PubMed] [Google Scholar]

80. Suratt BT, Cool CD, Serls A, Chen L, Varella-Garcia M, Shpall EJ, Brown KK, Worthen GS. Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med. 2003;168(3):318–322. doi: 10.1164/rccm.200301-145OC. [PubMed] [CrossRef] [Google Scholar]

81. Sydow M, Burchardi H, Ephraim E, Zielmann S, Crozier TA. Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ventilation and volume controlled inverse ratio ventilation. Am J Respir Crit Care Med. 1994;149(6):1550–1556. [PubMed] [Google Scholar]

82. Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med. 1999;5(4):434–438. doi: 10.1038/7434. [PubMed] [CrossRef] [Google Scholar]

83. Tharratt RS, Allen RP, Albertson TE. Pressure controlled inverse ratio ventilation in severe adult respiratory failure. Chest. 1988;94(4):755–762. [PubMed] [Google Scholar]

84. Theise ND, Nimmakayalu M, Cardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. Liver form bone marrow in humans. Hepatology. 2000;32(1):11–16. doi: 10.1053/jhep.2000.9124. [PubMed] [CrossRef] [Google Scholar]

85. Tomashefsk JF. Pulmonary pathology of the adult respiratory distress syndrome. Clin Chest Med. 1990;11(4):593–619. [PubMed] [Google Scholar]

86. Tuchschmidt J, Fried J, Astiz M, Rackow E. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest. 1992;102(1):216–220. [PubMed] [Google Scholar]

87. Walmrath D, Gunther A, Ghofrani HA, Schermuly R, Schneider T, Grimminger F, Seeger W. Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome. Am J Respir Crit Care Med. 1996;154(1):57–62. [PubMed] [Google Scholar]

88. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1334–1349. doi: 10.1056/NEJM200005043421806. [PubMed] [CrossRef] [Google Scholar]

89. Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation and repair. Am J Physiol Lung Cell Mol Physiol. 2002;282(5):L924–L940. [PubMed] [Google Scholar]

90. Windsor AC, Walsh CJ, Mullen PG, Cook DJ, Fisher BJ, Blocher CR, Leeper-Woodford SK, Sugerman HJ, Fowler AA3rd. Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation. J Clin Invest. 1993;91(4):1459–1468. [PMC free article] [PubMed] [Google Scholar]

91. Yamada M, Kubo H, Kobayashi S, Ishizawa K, Numasaki M, Ueda S, Suzuki T, Sasaki H. Bone marrow derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immuol. 2004;172(2):1266–1272. [PubMed] [Google Scholar]

92. Zapol WM, Trelstad RL, Coffey JW, Tsai I, Salvador RA. Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis. 1979;119(4):547–554. [PubMed] [Google Scholar]

93. Zapol WM, Snider MT, Hill JD, Fallat RJ, Bartlett RH, Edmunds LH, Morris AH, Peirce EC2nd, Thomas AN, Proctor HJ, et al. Extracorporeal membrane oxygenation in severe acute respiratory failure. JAMA. 1979;242(20):2193–2196. doi: 10.1001/jama.242.20.2193. [PubMed] [CrossRef] [Google Scholar]

94. Zhao YD, Campbell AI, Robb M, Ng D, Stewart DJ. Protective role of angiopoitin-1 in experimental pulmonary hypertension. Circ Res. 2003;92(9):984–991. doi: 10.1161/01.RES.0000070587.79937.F0. [PubMed] [CrossRef] [Google Scholar]

95. Zimmerman GA, McIntyre TM, Prescott SM. Adhesion and signaling in vascular cell-cell interactions. J Clin Invest. 1996;98(8):1699–1702. [PMC free article] [PubMed] [Google Scholar]

What happens in exudative phase of ARDS?

During the early (or exudative) phase, the lesion is characterized by high permeability pulmonary edema followed by the formation of hyaline membranes. After seven to ten days, a proliferative phase may develop, with marked interstitial inflammation, fibrosis, and disordered healing.

Which physical finding is most characteristic of the acute exudative phase of acute respiratory distress syndrome ARDS )?

Severe shortness of breath — the main symptom of ARDS — usually develops within a few hours to a few days after the precipitating injury or infection.

What are the three phases of acute respiratory distress syndrome?

Patients with ARDS tend to progress through three relatively discrete pathologic stages: the exudative stage, proliferative stage, and fibrotic stage.

What is the name of the period that follows the exudative phase in ARDS?

Respiratory failure during the exudative phase is attributed to accumulation of protein-rich fluid in distal airspaces and to decreased surfactant production by type II epithelial cells. These early events are followed by the proliferative phase, which develops 2–7 days after initiation of lung injury.