Indian J Crit Care Med. 2014 Mar; 18(3): 149–163. These guidelines, written for clinicians, contains evidence-based recommendations for the prevention of hospital acquired infections Hospital acquired infections are a major cause of mortality and morbidity and provide challenge to clinicians. Measures of infection control include
identifying patients at risk of nosocomial infections, observing hand hygiene, following standard precautions to reduce transmission and strategies to reduce VAP, CR-BSI, CAUTI. Environmental factors and architectural lay out also need to be emphasized upon. Infection prevention in special subsets of patients - burns patients, include identifying sources of organism, identification of organisms, isolation if required, antibiotic prophylaxis to be used selectively, early removal of necrotic
tissue, prevention of tetanus, early nutrition and surveillance. Immunodeficient and Transplant recipients are at a higher risk of opportunistic infections. The post tranplant timetable is divided into three time periods for determining risk of infections. Room ventilation, cleaning and decontamination, protective clothing with care regarding food requires special consideration. Monitoring and Surveillance are prioritized depending upon the needs. Designated infection control teams should
supervise the process and help in collection and compilation of data. Antibiotic Stewardship Recommendations include constituting a team, close coordination between teams, audit, formulary restriction, de-escalation, optimizing dosing, active use of information technology among other measure. The recommendations in these guidelines are intended to support, and not replace, good clinical judgment. The recommendations are rated by a letter that indicates the strength of the recommendation and a
Roman numeral that indicates the quality of evidence supporting the recommendation, so that readers can ascertain how best to apply the recommendations in their practice environments. Keywords: Hospital Acquired Infection prevention, Standard Precautions, Burns, Monitoring Surveillance, Antibiotic Stewardship Hospital acquired infections (HAIs) is a major safety concern for both
health care providers and the patients. Considering morbidity, mortality, increased length of stay and the cost, efforts should be made to make the hospitals as safe as possible by preventing such infections.[1,2] These guidelines have been developed for health
care personnel involved in patient care in wards and critical care areas and for persons responsible for surveillance and control of infections in hospital. The principles of the grading of recommendations assessment, development and evaluation (GRADE) system is used to guide assessment of quality of evidence from high (A) to very low (C) and to determine the strength of recommendations. Each recommendation is categorized on the basis of existing scientific data, theoretical
rationale, applicability and economic impact. The GRADE system classifies recommendations as strong (grade 1) or weak (grade 2). The assignment of strong or weak is considered of greater clinical importance than a difference in letter level of quality of evidence. The system for categorizing recommendations in this guideline is as follows. Evidence from at least one
properly-designed randomized, controlled trial Evidence from at least one well-designed clinical controlled analytic studies (preferably from more than one center), or from multiple time-series studies, or dramatic results from uncontrolled experiments Evidence from opinions of respected authorities based on the clinical experience, descriptive studies, or reports of expert committees. Strength of recommendation
General Measures of Infection ControlIsolation
Isolation rooms should have tight-fitting doors, glass partitions for observation and both negative-pressure (for source isolation) and positive-pressure (for protective isolation) ventilations. Patient at risk of nosocomial infectionsThere are patient, therapy and environment related risk factors for the development of nosocomial infection.[3]
Observe hand hygieneHands are the most common vehicle for transmission of organisms and “hand hygiene” is the single most effective means of preventing the horizontal transmission of infections among hospital patients and health care personnel.[4] When and why – follow World Health Organizations (WHO′s) five moments for hand hygiene [Figure 1] World Health Organization's five moments for hand hygiene
(Remember there are two moments before and three moments after touching the patient). How
Follow standard precautionsStandard precautions include prudent preventive measures to be used at all times, regardless of a patient's infection status.[4] Gloves Sterile gloves should be worn after hand hygiene procedure while touching mucous membrane and non-intact skin and performing sterile procedures (2A) e.g. arterial, central line and Foley catheter insertion
Gown
Mask, eye protection/face shield
Shoe and head coverings
Patient-care equipment
Follow transmission-based precautionsIn addition to standard precautions, the following should be observed in those patients known or suspected to have airborne, contact or droplet infections:[4] Airborne precautions
Contact precautionsInfections can be spread by usual direct or indirect contact with an infected person, the surfaces or patient care items in the room, for example, parainfluenza virus infection, respiratory syncytial virus infection, varicella (chickenpox), herpes zoster, hepatitis A and rotavirus infections.[4]
Droplet precautions
Use specific strategies focused on prevention of specific nosocomial infectionsIn addition to the standard and transmission-based precautions, there are several strategies focused on prevention of specific nosocomial infections in critically ill patients. Of these, ventilator-associated pneumonia (VAP), catheter-related bloodstream infection (CRBSI) and urinary tract infection (UTI) are the most important. Strategies to reduce VAP
Strategies to reduce CRBSI
Strategies to reduce UTI
Consider environmental factorsCleaning and disinfection
Architecture and layout, especially while designing a new ICU
Organizational and administrative measures[4,11]
Guidelines for Infection Prevention in Burns PatientsBurn wounds can provide optimal conditions for colonization, infection and transmission of pathogens; infection acquired by burn patients is a frequent cause of morbidity and mortality. Epidemiology of infectionThe development of infection depends on the presence of three conditions, a source of organisms; a mode of transmission; and the susceptibility of the patient. Source of organismsSources of organisms are found in the patient's own endogenous (normal) flora, from exogenous sources in the environment and from health care personnel. Although burn wound surfaces are sterile immediately following thermal injury, these wounds eventually become colonized with microorganisms.[12] Gram-positive bacteria that survive the thermal insult, such as staphylococci located deep within sweat glands and hair follicles, heavily colonize the wound surface within the first 48 h unless topical antimicrobial agents are used.[13] Eventually (after an average of 5-7 days), these wounds are subsequently colonized with other microbes, including Gram-positive bacteria, Gram-negative bacteria and yeasts derived from the host's normal gastrointestinal and upper respiratory flora and/or from the hospital environment or that are transferred via a HCW hands.[12,14] Mode of transmissionIn burn patients, the primary mode is direct or indirect contact-either through the hands of the personnel caring for the patient or from contact with inappropriately decontaminated equipment.[15] Burn patients are unique in their susceptibility to colonization from organisms in the environment as well as in their propensity to disperse organisms into the surrounding environment. In general, the larger the burn injury, the greater the volume of organisms that will be dispersed into the environment from the patient.
Patient susceptibilityThe patient has three principal defense against infection: Physical defenses, nonspecific immune responses and specific immune responses. Changes in these defenses determine the patient's susceptibility to infection. Invasive devices, such as endotracheal tubes, intravascular catheters and urinary catheters, bypass the body's normal defense mechanisms.[16,17] Culturing and surveillanceBurn wound flora and antibiotic susceptibility patterns change during the course of the patient's hospitalization so that the purposes of obtaining routine surveillance cultures are:
Isolation guidelines
Patients with >30% TBSA burn injuries are more immunocompromised, due to the larger size of their injury. This, in combination with their loss of physical defenses and need for invasive devices, significantly increases their risk of infection. These patients also represent a significant risk for contamination of their surrounding environment with organisms, which may then be spread to other patients on the unit. Environmental issues
Antibiotic prophylaxis
Early nutrition
Early enteral feeding is likely effective because it increases circulation to the bowel, thereby decreasing ischemia post-injury and the translocation of bowel flora. Prevention of tetanus
Bloodstream and intravascular catheter infection Whenever possible, catheters should be placed through unburned skin, preferably at a sufficient distance from the wound to prevent contamination of the insertion site. This is not always feasible in patients with large burn injuries, requiring long-term vascular access[28] (2B). Pneumonia Burn patients with severe inhalation injury requiring prolonged intubation are also at risk for developing VAP.
UTI
Guidelines for Infection Control in the Special Subsets - Immunocompromised and Transplant PatientsImmunocompromised patients are those patients whose immune mechanisms are deficient because of immunologic disorders (e.g. human immunodeficiency virus (HIV) infection or congenital immune deficiency syndrome), chronic diseases (e.g. diabetes, cancer, emphysema, or cardiac failure), or immunosuppressive therapy (e.g. radiation, cytotoxic chemotherapy anti-rejection medication, or steroids). Immunocompromised patients who are identified as high-risk patients have the greatest risk of infection caused by airborne or waterborne microorganisms. Patients in this subset include persons who are severely neutropenic for prolonged periods of time (i.e. an absolute neutrophil count (ANC) of <500 cells/mL), allogeneic HSCT patients and those who have received the most intensive chemotherapy (e.g. childhood acute myelogenous leukemia patients).[30] In general, opportunistic infections result from at least 1 of 3 basic mechanisms: (1) Exogenous acquisition of a particularly virulent pathogen (e.g. meningococcal meningitis or pneumococcal pneumonia), (2) reactivation of an endogenous latent organism (e.g. herpes simplex virus, herpes zoster virus [HZV or shingles], or tuberculosis and (3) endogenous invasion of a normally commensal or saprophytic organism (e.g. bacteria, viruses, fungi, or protozoa/parasites). The post-transplant timetable can be divided into three time periods:[31]
Hand hygiene
Isolation
Room ventilation
Cleaning
Guidelines exist for floor space in ICUs (ESICM and SCCM references). The transmission of micro-organisms will occur more readily in cramped conditions. There are recommendations for the number of isolation cubicles that should be available for patients with resistant organisms and for immunocompromised patients.[37,38] Protective clothing
Food and drink
Pharmacological prophylaxis against diseases in transplant patients may be done as per recommendations in the references mentioned.[40,43,44] Monitoring of Infection ControlWhat should be monitored? Monitoring includes various aspects of infection control practices [Table 1]. Simultaneous monitoring of all the aspects might not be possible therefore prioritization must be done by the infection control team depending upon the need and situation. Monitoring of process compliance is most important to reduce incidence of HAI, preventing multidrug resistance to antimicrobials and protecting HCWs from getting infection. Methodology of monitoring should be adopted as per the institutional policy.[45,46,47] Environmental monitoring along with microbiological surveillance has been claimed to reduce infection rate. Adherence to hand hygiene is being considered as one of the most important preventive action.[47] Observed adherence to hand hygiene protocol ranges from 5% to 89% (38.7%) among the HCWs. Table 1Monitoring of Infection Control Process related recommendations
Who should monitor: Designated infection control nurses should supervise the process and help in collection and compilation of data. However, for case controlled study of an outbreak, the primary investigating team should include the hospital epidemiologist, the director of employee health, the infection-control team and microbiologist. External consultants might be necessary in some cases.[54] How to monitor: Following methods had been advocated for monitoring HAI data.[56]
Observation Direct observation is the gold standard to monitor compliance with optimal hand hygiene practice. Monthly monitoring of hand hygiene product consumption (Soap, alcohol rub) had also been advocated as an indirect measure of hand hygiene but this needs further validation. Number of dispenser filled with alcohol rub and number of dispenser working when compared to total number of dispensers available are also simple monitoring parameters.[57] Predesigned format for survey, inspection and interview Data collection and compliance monitoring are facilitated if a format is available for doing so.[58] For full, partial and minimal compliance >85%, 76-84% and <75% respective scores had been suggested.[59] Surveillance Surveillance is defined as ‘′ongoing, systematic collection, analysis and interpretation of health data essential to the planning, implementation and evaluation of public health care practice. It is closely integrated with timely dissemination of these data to those who need to know.′’[58,60] Periodicity of data collection Frequency of data collection, analysis and generation of report for evaluation and taking corrective measures should also be predefined.[54] If data is being collected intermittently then, it should be done at least for four continuous weeks in each time period under study.[58] Authenticity of data remains a matter of concern therefore source of data should always be mentioned and its must be verified before relying on the same for decision making. Data can be presented as pooled mean, median and percentile manner. Team should further analyze and investigate extremely higher or lower rate or ratio (>90th percentile, ≤10th percentile).[61] Automated monitoring Automated monitoring helps in avoiding errors and variability related to manual collection of data. Hospitals with sophisticated information systems are in a position to streamline surveillance process through computer-based algorithms that identifies patients at highest risk of HAI.[54] Computerized surveillance helps in better implementation of preventive strategies, but lower infection rates had not been proven conclusively.[62,63] The use of sinks and hand rub dispensers had also been used for electronic monitoring of hand hygiene practice.[4,57] Endemic rate of infection Surveillance of endemic infection is the focal point of infection control activity. It helps in generating a data base and identifying epidemic when incidence crosses the endemic threshold.[47] The first aim of surveillance is to determine endemic rate of infection.[54] The base line data of HAI helps in taking improvement initiatives. It has been claimed that infection rate can be reduced by 31-44% with the implementation of effective surveillance system.[18,64] Outbreak investigation Investigation for outbreak should be considered when monthly incidence of a particular type of infection is more than 95% of the confidence interval of same infection in the same month in the previous year.[54] Analysis of all isolates, patients’ demographic data and exposure to potential risk factors (medication, procedure and contact) are necessary for such investigation. This should be followed by analysis of time interval between infection and exposure to potential risk factors. Based on the generated data, case controlled study is recommended according to age, gender and exposure to potential risk factors. This exercise helps in developing a hypothesis regarding source and transmission of infection. Temporary infection control measures are implemented based on the hypothesis formed. Molecular typing is advocated if such facilities are available.[54] Coding of clinical indicators, trend analysis and bench marking Use of ICD-10-AM codes for clinical indicators of infection control is desirable as it helps in data collating and benchmarking between health care institutions. However, all indicators do not have their ICD code.[58] Interhospital comparison of HAI demands standardization of definitions, data collection and analysis.[65] Therefore comparison of data might not be justified always due to differences in the infrastructure, quantitative and qualitative gap in human resource, compliance level, variation in the practices and case mix. Such exercise is further constrained because tools needed to compare infection rates for a given case mix is provided by very few systems.[65] Trend monitoring of unit's own data over a period of time therefore is more appropriate.[66] Organism prevalence, sensitivity pattern and antimicrobial use Tracking of organism prevalence, sensitivity pattern and antimicrobial use should be part of epidemiology program. Community acquired and HAI should be separated while analyzing the data.[54] Active and aggressive surveillance of all isolates and patients has been advocated on admission and weekly basis provided higher risk for carrying MRSA and VRE is anticipated. More frequent culture had been advised if >50% isolates are MRSA positive.[67] But this approach has been challenged.[68] Recommendations for Antimicrobial Stewardship
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Which client is most likely to require hospitalization related to problems associated with the feet quizlet?Which client is most likely to require hospitalization related to problems associated with the feet? Foot problems, particularly common in people with diabetes and peripheral vascular disease, often require hospitalization. The nurse assists the client to the bathroom sink to perform morning care.
Which of the following is one of the most important benefits of a nurse helping with bathing?One important benefit of a nurse helping a patient with bathing is that the nurse can help the patient to avoid injury. For example, the nurse can help the patient to avoid slipping in the tub or shower, and can also help the patient to avoid getting soap in their eyes.
When the nurse cleanses the clients leg during a bed bath it will allow for?When the nurse cleanses the client's leg during a bed bath, it will allow for: increased circulation. Bathing increases circulation and helps maintain muscle tone and joint mobility. A client age 78 years with diabetes needs to have his toenails trimmed.
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