Which rationale supports gene and stem cell therapy for a patient who has critical limb ischemia

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Color changes of fingers from white to blue to red

The vasospasm-induced color changes (from white to blue to red) of fingers, toes, ears, and nose are the usual characteristics of Raynaud's disorder. Decreased perfusion leads to pallor (white), followed by cyanotic (bluish purple) digits that further turn red when blood flow is restored. In the later phases of the disease, the patient may complain about numbness and coldness along with throbbing, tingling, and swelling. Chronic ischemic pain and ulceration may indicate peripheral arterial disease, whereas hypertension, hyperglycemia, and inflamed arteries may indicate one or more cardiovascular disorders.

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Which treatment may help prevent amputation in patients with critical limb ischemia?

Optimal medical therapy can reduce the risk of major adverse cardiovascular and limb events, but revascularization combined with close wound care remains the cornerstone of amputation prevention.

What does PAD stand for in medical terms?

Related Pages. Peripheral arterial disease (PAD) in the legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis.
Risk factors for atherosclerosis, include:.
High cholesterol and triglyceride levels..
High blood pressure..
Smoking..
Type 1 diabetes..
Obesity..
Physical inactivity..
High saturated fat diet..

What does the term intermittent claudication refer to?

Intermittent claudication is pain affecting the calf, and less commonly the thigh and buttock, that is induced by exercise and relieved by rest. Symptom severity varies from mild to severe. Intermittent claudication occurs as a result of muscle ischaemia during exercise caused by obstruction to arterial flow.