USDA-APHIS Animal Care Resource Policy #12 "Considerations of Alternatives to Painful/Distressful Procedures" states that when a database search is the primary means of considerations to alternatives of painful and distressful procedures, that a narrative should include all of the following except: Show
C. The specific field of study Which of the following should be considered a significant change to an animal use proposal? C. change in anesthetic agent Which of the following entities are required to release information per the Freedom of Information Act? Training and instruction of personnel must include guidance in which of the following areas? D. Research or testing methods that limit the use of animals Which of the following procedures may correctly be applied to Designated Member Review? A. The IACUC Chair appoints one member to do the Designated Member Review. In which of the following circumstances may animal work begin before receipt of IACUC approval? D. There are no circumstances in which animal work may begin before IACUC approval. Which of the statements below about the responsibility and authority of the Institutional Official (IO) is false? C. The IO may reinstate an animal activity that was previously suspended by the IACUC. With regard to conducting official IACUC business, the definition of a quorum is: A. More than fifty percent (a majority) of voting members The proper sequence for a designated member review by the IACUC is: A. Review materials are sent to all voting members, full committee review is not requested by any member, the chairperson assigns one or more IACUC members as designated reviewers. Notifying investigators of IACUC protocol review outcomes in writing is: C. Required by both the USDA Animal Welfare Act Regulations and PHS Policy. According to the Animal Welfare Act Regulations of the USDA, when conducting a semi-annual evaluation, the IACUC must conduct the evaluation: B. With at least 2 IACUC members and allow participation by any member who wishes to do so. Who is
given the authority to decide if a deficiency identified during a semi-annual IACUC evaluation is significant or minor? A. The IACUC and IO together. What information must be provided in the report for deficiencies
identified during the IACUC semi-annual self-evaluation? B. A reasonable and specific plan for correcting significant and minor deficiencies and a schedule for completing the corrective actions. Which of the following institutions must follow the PHS Policy? D. Institutions that accept PHS funding. The three Rs of Russell and Burch stand for what?
C. Replacement, reduction, and refinement. What is a primary mission of the Animal Welfare Information Center (AWIC)? B. Provides assistance with alternatives and database searches. Which agency requires an annual report
of the number of animals used by pain/distress category? D. United States Department of Agriculture Regarding studies with
infectious agents in animals, as the BSL and ABSL number increases from 1 to 4, what happens to the containment and safeguard practices? D. They become more stringent. U.S. Government Principles on the Use of
Animals in Research state that: D. Procedures that are painful to humans should be assumed to cause pain in animals unless there is evidence to the contrary. Which of the statements below about the responsibility and authority of the Institutional Official (IO) is false? C. The IO may reinstate an animal activity that was previously suspended by the IACUC. PHS policy states that the OLAW requires assurance renewal every:
The guide incorporated two must to Diaster Planning and Emergency Prepardness which involved: For the VA semiannual program review and facility inspection report, which of the following need not be included: c. The signatures of the majority of the voting members According to the Guide, who can conduct Post-Approval Monitoring (PAM)? According to PHS, awardee institutions shall maintain good
recordkeeping. Which one is not a recordkeeping requirement? The 8th addition of the guide incorporated new additions to the guide: IACUC, IACUC Training, Personnel Security, Investigating and Reporting Animal Welfare Concerns, Veterinary Clinical Care Management, Drug Storage and Control. According to the Guide, what item not a requirement for IACUC members: b) Training by a certified veterinarian on all procedures involving animals Which of the following is not required for IACUC membership according to the Ag
Guide: a. veterinarian with training or experience in laboratory animal science and medicine USDA Regulations require the following IACUC members: 1. Veterinarian, chair, nonaffiliated PHS Policy requires the following
IACUC members: 3. Veterinarian, nonaffiliated, scientist, nonscientist PHS and AWRs state that all records should be kept for a minimum of: PHS institutional Assurance is approve up to ___ years where as USDA registration is updated every ___ years: b) up to 5 years for PHS and 3 years FOR USDA Which is not required when filing a PHS Institutional Assurance: c) Number of covered species used annually If the institution is PHS assured and is not AAALAC accredited, what must be included in the annual report to OLAW? c) Semiannual IACUC report
What are the two circumstances that you would submit a semiannual report to OLAW? At the request of OLAW or if your institutional is not assured by a accrediting body such as AAALAC What line of authority submits the annual report to OLAW? Where do you send the USDA annual report? APHIS AC Regional Director. When there is a change in name of institution, or ownership or operation for the research facility how many days do you have to notify the APHIS AC Regional Director of the change? Notify within 10 days of change in operation.
According to USDA, failure to correct a significant deficiency in accordance to a specific schedule and plan must be reported to APHIS and any other federal agency within ____days by who_____? Notify within 15 days by the IACUC through the IO. There are three main circumstances for prompt report to PHS, which one of the three
circumstances below must be reported promptly to USDA: When there are allegations of concerns on animal care and use, what are recommended steps for the IACUC when investigating the concern: True or False. If a facility that receives DoD funds is under USDA investigation, the facility must notify DoD and have a site visit within 30 days of notification. True or False. The Secretary of the Army as Executive Agent develops and issues joint service regulations to implement the Department of Defense Directive number 3216.1. True or False. DoD Activities performed or sponsored in foreign countries shall follow all applicable US requirements, as well as regulations and standards of the host country. True or False. The non-affiliated member(s) on a DoD IACUC may be a federal employee with demonstrated commitment to the community. True or False. DoD organizations/facilities are not required to apply for AAALAC accreditation. True or False. Violation complaints within the DoD can only be reported to the Inspector General. True or False. The Department of Defense directive indicates that any species may be purchased or used for inflicting wounds from any type of weapon to conduct training in surgical/medical treatment procedures. True or False. The Joint Technical Working Group (JTWG) acts as a central advisory committee to the Armed Services Biomedical Research Evaluation and Management (ASBREM) Committee. The Executive Agent designates the Commander of the US Army Veterinary Command, the Director of Veterinary Services Activity, the
Director of Defense Research and Engineering and: Which of the following are applicable to the Department of Defense: The Executive Agent for the Department of Defense Directive number 3216.1
is the _____ According to the 8th edition of the Guide each institution must or should have an occupational health program in place consistent with federal, state and local regulations? True or False: Institution procuring animal must have lawful procedures in place as well as procedures for compliance with animal transportation regulations to include international requirements. Programs for medical evaluation preventative medicine include all the following except: Which of the following is not typically a function of the IACUC? C. Review and score scientific value for animal protocols submitted. Which of the following is a
required member of the IACUC? C. Individual not otherwise affiliated with the institution According to USDA Regulations, an IACUC may have no more than how many members from any one
administrative unit? Which of the following statements concerning confidentiality of IACUC business is false? D. Confidentiality requirements prohibit IACUC members from reporting violations of the Animal Welfare Act Regulations or PHS Policy. What do the Animal Welfare Act Regulations state about IACUC members who report violations to USDA? C. It is against the law for anyone to discriminate against them or subject them to reprisals. OLAW recommends which of the following reporting lines within an animal care and use program? B. Attending Veterinarian reports to the Institutional Official Which of the following statements about OLAW's guidance on the use of carbon dioxide as a euthanasia agent is false? A. Carbon dioxide must be supplied only from compressed gas cylinders. Which of the following statements
about IACUC suspensions of animal activities is false? A. USDA Animal Welfare Act Regulations and PHS Policy allow the chairperson or another IACUC member to suspend an animal activity on behalf of the IACUC. When reporting an IACUC suspension of an animal activity, the IACUC should: B. Report the suspension as soon as possible to the regulatory authorities. Which of the following statements regarding the process of polling IACUC members via email is true? D. Polling via email can be used to allow the IACUC members to call for full committee review when using the designated reviewer system. Which of the following statements about the use of
"alternate" IACUC members is false? C. Alternate members may vote on an issue even when the regular member is present and votes on the same issue. Which of these IACUC protocol review outcomes are recognized in the USDA Animal Welfare Act Regulations and PHS Policy? C. Approve, require modifications in (to secure approval), and withhold approval Although opinions vary about the level of detail needed in IACUC minutes, a typical standard
is that IACUC minutes: B. Should allow an outside observer to verify that deliberations occurred, and understand the outcomes of those deliberations. When conducting the facilities inspection portion of the semi-annual evaluation in compliance with both the USDA Animal Welfare Act Regulations and PHS Policy, the IACUC must include: D. All areas housing animals for more than 12 hours, and laboratories where animal procedures are performed with the exception of laboratories performing only non-survival surgical procedures. To comply with the
USDA Animal Welfare Act Regulations, what is the proper IACUC course of action to follow if a significant deficiency is not corrected according to the plan set forth in the IACUC semi-annual evaluation report? D. Report the situation through the IO to USDA within 15 business days. Which of these statements is true concerning the USDA Animal Welfare Act? D. The Animal Welfare Act regulations take precedence over guidelines produced by the Public Health Service, Department of Veterans Affairs, and other government agencies. Which of the following is not an example of replacement? C. The use of a new analgesic that provides better postoperative pain relief. Which of the following is not an example of reduction? A. The use of a new anesthetic that provides better induction and a shorter recovery period. Which of the following is not an example of refinement? C. The use of computer modeling software to substitute for animal experiments. What is required, of the IACUC, by the USDA AWA Regulations regarding alternatives? D. Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available. What is the basis for the pain/distress classification system used by most
institutions? C. USDA pain/distress categories. Which of the following activities would disqualify an animal from USDA category B? Which of the following activities would disqualify an animal from USDA category D? D. Studies in which animals are allowed to die without pain relief. An investigator wishes to use animals in an experiment that involves category B, C, and D activities performed on the same animal. How should the animal be categorized? Which of the following activities would place an animal in category E? A. Lethal dose experiments in which animals are allowed to die without intervention. All personnel performing animal procedures must be properly trained to do so when? B. Before any procedures are performed. Which statement about the Occupational Health and Safety Program is false? C. You may not decline medical treatments provided as part of the Occupational Health and Safety Program. Which of the following is false concerning prolonged restraint of animals? B. It can be justified as a convenience for the research staff. Which of the following is true of the dog exercise program mandated by the USDA Animal Welfare Act regulations? B. The IACUC can exempt an animal for scientific Great Southern Agricultural and Technical University has an Animal Welfare Assurance Statement on file with OLAW that covers all PHS funded projects. The University's policy states that all use of live vertebrate animals for teaching and research
requires IACUC review and approval. A faculty member contacts the IACUC Chair to report that he demonstrated a blood sampling procedure on a live chicken for a teaching lab, but it was not the blood sampling method described in the IACUC approved protocol for the lab. The IACUC must report this noncompliance to: The institution's PHS Assurance applies to PHS-funded projects only. An investigator has two IACUC protocols using mice. Protocol A (NIH funded) stipulates that animals will be killed by barbiturate overdose while decapitation would be the method used in Protocol B (private foundation funds). The investigator informs the IACUC Office that his staff mistakenly euthanized a few animals assigned to Protocol B with barbiturate overdose. How should the IACUC respond? a) Suspend the investigator. a) you could suspend, but it's not required, and would probably make people mad at the IACUC. Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook Which entity does not require the IACUC to have a scientific member? USDA Source: Certified Professional IACUC Administrator (CPIA)
Study Group - Facebook Which of the following statements is true about routes of administration for injectable agents? a. When performing an IP injection, the drug must also contain a neuromuscular blocking agent. c. IC injection is acceptable when the animal is either heavily sedated, anesthetized, or comatose. Source: AALAS Learning Library What is the recommended concentration of carbon monoxide used for euthanasia of small mammals? a) Over 10% d) 4-6% Source: AALAS Learning Library Under what circumstance is the IV or IC injection of potassium chloride an acceptable euthanasia method? a) When other methods have failed d) If the animal is anesthetized Source: AALAS Learning Library For which species is an adjunctive method of euthanasia is recommended to make sure that the animal is dead because detection of heartbeat is difficult in these animals? a) Fish c) Small rodents Source: AALAS
Learning Library Physical methods of euthanasia cause death through destruction of: a) muscular activity in the body. d) midbrain centers controlling respiratory and cardiac activity. Source: AALAS Learning Library A reflex movement during the euthanasia procedure indicates that the unconscious animal is still experiencing pain. a) True b) False Source: AALAS Learning Library Which of the following statements is true of barbiturates? a) Barbiturates cause the animal to gasp for air
before becoming unconscious indicating some pain and distress. b) These drugs are extremely painful when administered outside the vein. Source: AALAS Learning Library Which of the following statements regarding physical methods of euthanasia is true? a) There are few aesthetic considerations for this form of euthanasia. b) Physical methods of euthanasia may be the most humane method for relieving pain and suffering in some instances. Source: AALAS Learning Library
In special circumstances that may indicate a need to deviate from the AVMA guidelines, what should be the deciding factor? a) The cost of the procedure b) The best interest of the animal Source: AALAS Learning Library Cervical dislocation should not be performed in rabbits weighing more than: a) 500 g. d) 1 kg. Source: AALAS Learning Library Which of the following statements is true about the use of carbon monoxide for euthanasia? a) Acceptable for individual or mass euthanasia of cattle, horses, and other large mammals. c) Death occurs rapidly at concentrations of 4 to 6%. Source: AALAS Learning Library Confirmation of death is determined by: a) Lack of movement c) Cessation of vital signs Source: AALAS Learning Library What is the mode of euthanasia action for an overdose of barbiturates? a) Depresses the CNS leading to cardiac arrest a) Depresses the CNS leading to cardiac arrest Source: AALAS Learning Library
Which of the following is a definition of euthanasia as described in the AVMA Guidelines? a) The act of killing animals by methods that preserve physiologic function after death b) The act of killing animals by methods that induce rapid unconsciousness and death with minimal pain or distress Feedback: Euthanasia as defined by the Animal Welfare Act (AWA): ""The humane destruction of an animal must be accomplished by a
method that produces rapid unconsciousness and subsequent death without evidence of pain or distress, or a method that utilizes anesthesia produced by an agent that causes painless loss of consciousness and subsequent death."" Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines Euthanasia agents that act by way of hypoxia are not recommended for which of the following groups of animals? a) Warm-blooded neonates a) Warm-blooded neonates Source: AALAS Learning Library Which of the following statements is true about inhalant agents used for euthanasia? a) Since inhalant anesthetic effects are specific to the animal species being euthanized, no special precautions for personnel are required. d) Animals should be protected from contact with the liquid form of the anesthetic agent. Source: AALAS Learning Library Which of the following statements is true when using CO2 for euthanasia? a) It is best to combine carbon dioxide with oxygen for euthanasia. d) Gas flow should be maintained for at least 1 minute after apparent death to make sure the animal does not recover. Source: AALAS Learning Library Immersing aquatic species in a bath saturated with carbon dioxide is an acceptable euthanasia method. a) True a) True Source: AALAS Learning Library Which of the following statements concerning euthanasia is incorrect? a) Physical methods of euthanasia
are most desirable when used on conscious animals. a) Physical methods of euthanasia are most desirable when used on conscious animals. Source: AALAS Learning Library Chloral hydrate is conditionally acceptable for use in large animals that: a) are already sedated. a) are already sedated. Source: AALAS Learning Library Which of the following mandates require the provision of occupational health services for employees who work in animal facilities? a) Occupational Health and Safety Act d) PHS Policy Source: AALAS Learning Library Serum collection and storage may be of value in which of the following situations? a) A veterinary technician is providing medical care to rabbits in safety assessment studies. b) Employees have a substantial possibility of acquiring an infection that can be detected serologically. Source: AALAS Learning Library Which person is primarily responsible for developing and sustaining a useful occupational health and safety program? a) IACUC chairperson b) Senior institutional official Source: AALAS Learning Library Which of the following statements is false concerning shigellosis? a) Very large numbers of organisms are required to produce an infection. a) Very large numbers of organisms are required to produce an infection Source:
AALAS Learning Library The effectiveness of the autoclave can be monitored by using: a) Paper strips or vials containing bacterial spores a) Paper strips or vials containing bacterial spores Source: AALAS Learning Library Which of the following are in a unique position to monitor the daily effectiveness of and compliance with health and safety procedures in a laboratory animal program? a) Principal investigators b) Animal care staff Source: AALAS Learning Library Which of the following statements is true concerning dermatomycosis? a) Infected animals usually have several obvious lesions. d) None of the above Source: AALAS
Learning Library Which of the following is not an effective means of identifying hazards? a) Consulting personnel from governmental agencies (e.g., NIH, CDC, OSHA) b) Considering only those hazards that previously caused obvious illness or injury Source: AALAS Learning Library How often should biological safety cabinets be certified? a) At the time of the IACUC inspection d) At least once a year Source: AALAS Learning Library Which of the following is not considered to be a major mode of transmission of the herpes B-virus? a) Needle stick c) Aerosol Source: AALAS Learning Library Which of the following viruses causes a disease similar to smallpox but much less severe? a) Measles b) Benign epidermal monkeypox Source: AALAS
Learning Library Which of the following infections is particularly hazardous to a human fetus? Which disease is not readily transmitted to humans through
animal bites? What are allergic reactions seen within 10 to 15 minutes of exposure called? b) Immediate hypersensitivity Occupational health and safety programs intended to protect employees in animal facilities should be the same at all institutions where research animals are housed. Which of the following is not a hazardous property of a chemical? The use of radioisotopes is regulated by what agency? a) US Nuclear Regulatory Commission Which of the following should not be a consideration when selecting proper equipment for facilities? Which of the following statements is true? a) Female mice excrete four times as much allergen as males. c) Sensitivity to mouse allergen is common Which of the following is not a good method to prevent Q fever infection in laboratory workers? a) Rely on serology in sheep to detect shedding of the organism. What is included in Animal Welfare Regulations for housing guinea pigs and/or hamsters? b) Cages for hamsters must be at least 5 inches high. Who has the legal authority to sign the USDA registration form of a research institution? b) The Institutional Official How frequently does the USDA conduct inspections of research facilities? Dogs obtained from a Class B dealer may originate from what source? What is one objective of the annual report to the USDA/APHIS? a) Assure that the facility complies with the AWA standards and regulations. Record-keeping requirements of the Animal Welfare Regulations state that: d) IACUC records for meeting minutes, protocols and semiannual reports must be available to USDA inspection. What determines cage space requirements for nonhuman primates as outlined in the Animal Welfare Regulations? c) Weight group of the nonhuman primates The AWA Regulations require that the attending veterinarian must: a) Approve animal use protocols. b) Have authority to ensure adequate veterinary care. What is not required by Animal Welfare Regulations for transport cages? b) An elevated screened bottom to keep animals off the floor of the cage Which statement is TRUE about exercise plans for dogs? d) Exercise plans are required for all facilities housing dogs. What type of identification is not acceptable for dogs or
cats at acquisition? d) Distinctive color markings Which statement is TRUE regarding health requirements for shipping animals: b) Health certificates must accompany any dog, cat or nonhuman primate transported by a research facility. Animal Welfare Regulations for rabbits require: b) Cages to be sanitized once every 30 days. What change was made to the Animal Welfare Act by the 1990 pet protection amendment? c) Cats and dogs must undergo a 5-day holding period before being acquired by a dealer. Which of the following information need not be present on an official tag? What requirement does the Animal Welfare Act place on multiple survival
surgery? a) Multiple survival surgeries are permitted when scientifically justified. Which of the following is NOT a responsibility of the IACUC? d) Specifying veterinary treatments to be administered to facility animals. A person supplying dogs to research is exempted from licensing with the USDA under which of the following conditions? b) Fewer than 25 dogs born on their premises are sold within a one-year period. What space requirements for cats are included in the Animal Welfare Regulations? a) If clean and sanitized, the litter box can be counted as floor space. Record-keeping
requirements of the Animal Welfare Regulations state that: c) Acquisition records must be maintained for dogs and cats that are received by the facility. Reports prepared by the IACUC during semiannual facilities inspections must distinguish between minor and significant deficiencies. Which of the following best describes a significant deficiency? a) Poses a threat to the health and safety of the animals On behalf of an institution, which individual is ultimately responsible for compliance with PHS Policy? d) Institutional Official Which of the following statements is TRUE? b) Sheep used in a study testing different ways to improve the quality of wool for use in clothing would NOT be covered by the Animal Welfare Act. According to the PHS policy, any building, room, or area used for confinement, transport, or experiments including surgery is considered an animal facility if the animals are maintained there for more than ______ hours. a) 48 Which of the following is true regarding the IACUC authority and responsibilities regarding research animal misuse mistreatment or noncompliance?Which of the following is true regarding the IACUC's authority and responsibilities regarding research animal misuse, mistreatment, or noncompliance? If the IACUC decides that any animal activities must be stopped to protect either animals or humans, it is given clear regulatory authority to do so.
Which of these full committee review outcomes do the AWR and PHS Policy allow?Which of these IACUC protocol review outcomes is recognized in the Animal Welfare Regulations (AWR) and PHS Policy? Approve, require modifications in (to secure approval), and withhold approval.
When conducting the facilities inspection portion of the semiannual evaluation in compliance with both the AWR and PHS Policy The IACUC must include?When conducting the facilities inspection portion of the semi-annual evaluation in compliance with both the Animal Welfare Regulations and PHS Policy, the IACUC must include all areas housing animals for more than: 12 hours, and all investigator laboratory and study areas where surgery is performed.
Which of the following is a function of the IACUC?Responsibilities. The IACUC is responsible for oversight of the animal care and use program and its components as described in the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (Policy) and the Guide for the Care and Use of Laboratory Animals (Guide ).
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